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Small molecule inhibition of non-canonical (TAK1-mediated) BMP signaling results in reduced chondrogenic ossification and heterotopic ossification in a rat model of blast-associated combat-related lower limb trauma.
Strong, Amy L; Spreadborough, Philip J; Pagani, Chase A; Haskins, Ryan M; Dey, Devaveena; Grimm, Patrick D; Kaneko, Keiko; Marini, Simone; Huber, Amanda K; Hwang, Charles; Westover, Kenneth; Mishina, Yuji; Bradley, Matthew J; Levi, Benjamin; Davis, Thomas A.
Afiliação
  • Strong AL; Division of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, United States of America.
  • Spreadborough PJ; Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, MD, United States of America; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America; Academic Department of Military Surgery and Trauma, Royal Centre for Defe
  • Pagani CA; Division of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, United States of America.
  • Haskins RM; Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, MD, United States of America.
  • Dey D; Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, MD, United States of America; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America.
  • Grimm PD; Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, MD, United States of America; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America.
  • Kaneko K; Division of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, United States of America.
  • Marini S; Division of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, United States of America.
  • Huber AK; Division of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, United States of America.
  • Hwang C; Division of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, United States of America.
  • Westover K; Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States of America.
  • Mishina Y; Department of Biologic and Materials Science and Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI, United States of America.
  • Bradley MJ; Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, MD, United States of America; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America.
  • Levi B; Division of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, United States of America. Electronic address: blevi@med.umich.edu.
  • Davis TA; Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, MD, United States of America; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America. Electronic address: thomas.davis@usuhs.edu.
Bone ; 139: 115517, 2020 10.
Article em En | MEDLINE | ID: mdl-32622875
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteogênese / Ossificação Heterotópica Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Bone Assunto da revista: METABOLISMO / ORTOPEDIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteogênese / Ossificação Heterotópica Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Bone Assunto da revista: METABOLISMO / ORTOPEDIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos