Exomphalos without other prenatally detected anomalies: Perinatal outcomes from 22 years of population-based data.
Prenat Diagn
; 40(10): 1310-1314, 2020 09.
Article
em En
| MEDLINE
| ID: mdl-32643302
ABSTRACT
OBJECTIVE:
To ascertain the perinatal outcomes for an apparently isolated exomphalos detected by prenatal ultrasound.METHOD:
Our dataset captures cases from 614 321 births in the Wessex region of England and the Channel Isles on all cases of pre- or postnatally diagnosed exomphalos from 1994 to 2015. Ascertainment was >95%.RESULTS:
Three hundred and thirty five cases were reported to the register 28 (8%) were not detected prenatally, 18 (6%) had already died in utero, 169 (55%) cases were found to have additional anomalies on first tertiary ultrasound scan and one case was lost to follow-up. Therefore 119 (39%) cases had an apparently isolated exomphalos. Of the 119 cases with only an exomphalos detected on first tertiary ultrasound scan, 25 (21%) had a chromosome abnormality. Of those with a normal or untested karyotype, 61% were confirmed to be an isolated anomaly after birth, 13% had an additional heart abnormality, 9% had Beckwith-Wiedemann syndrome and 11% had additional problems diagnosed postnatally.CONCLUSION:
Our large population-based dataset with an average of 1 year's postnatal follow-up suggests that more than one-third of apparently isolated prenatal cases of exomphalos will have an additional finding detected after birth. These data should help assist clinicians in their prenatal counseling.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Resultado da Gravidez
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Hérnia Umbilical
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Newborn
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Pregnancy
País/Região como assunto:
Europa
Idioma:
En
Revista:
Prenat Diagn
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Reino Unido