A new diterpenoid from the leaves of Phyllanthus acidus.
Nat Prod Res
; 36(2): 539-545, 2022 Jan.
Article
em En
| MEDLINE
| ID: mdl-32643407
ABSTRACT
A new diterpenoid, phyllane C (1), along with three known compounds, ovoideal E (2), spruceanol (3), and fluacinoid B (4) were isolated from the leaves of Phyllanthus acidus growing in Thailand. The structures were determined by analysis of their MS and NMR data as well as by comparison with literature values. DFT-NMR chemical shift calculations and subsequent DP4/DP4+ probability methods were applied to define the relative configuration of 1. Compound 3 showed a weak cytotoxicity against K562 cell line (IC50 41.9 ± 2.31 µg/mL).
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Phyllanthus
/
Diterpenos
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Vietnã