Assessment of emotions and behaviour by the Developmental Behaviour Checklist in young people with neurodevelopmental CNVs.
Psychol Med
; 52(3): 574-586, 2022 02.
Article
em En
| MEDLINE
| ID: mdl-32643597
ABSTRACT
BACKGROUND:
A number of genomic conditions caused by copy number variants (CNVs) are associated with a high risk of neurodevelopmental and psychiatric disorders (ND-CNVs). Although these patients also tend to have cognitive impairments, few studies have investigated the range of emotion and behaviour problems in young people with ND-CNVs using measures that are suitable for those with learning difficulties.METHODS:
A total of 322 young people with 13 ND-CNVs across eight loci (mean age 9.79 years, range 6.02-17.91, 66.5% male) took part in the study. Primary carers completed the Developmental Behaviour Checklist (DBC).RESULTS:
Of the total, 69% of individuals with an ND-CNV screened positive for clinically significant difficulties. Young people from families with higher incomes (OR = 0.71, CI = 0.55-0.91, p = .008) were less likely to screen positive. The rate of difficulties differed depending on ND-CNV genotype (χ2 = 39.99, p < 0.001), with the lowest rate in young people with 22q11.2 deletion (45.7%) and the highest in those with 1q21.1 deletion (93.8%). Specific patterns of strengths and weaknesses were found for different ND-CNV genotypes. However, ND-CNV genotype explained no more than 9-16% of the variance, depending on DBC subdomain.CONCLUSIONS:
Emotion and behaviour problems are common in young people with ND-CNVs. The ND-CNV specific patterns we find can provide a basis for more tailored support. More research is needed to better understand the variation in emotion and behaviour problems not accounted for by genotype.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Variações do Número de Cópias de DNA
/
Lista de Checagem
Limite:
Adolescent
/
Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Psychol Med
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Reino Unido