Opportunities and challenges for drug discovery in modulating Adhesion G protein-coupled receptor (GPCR) functions.

Bondarev, Andrey D; Attwood, Misty M; Jonsson, Jörgen; Chubarev, Vladimir N; Tarasov, Vadim V; Schiöth, Helgi B

Bondarev, Andrey D; Attwood, Misty M; Jonsson, Jörgen; Chubarev, Vladimir N; Tarasov, Vadim V; Schiöth, Helgi B.

Afiliação

Bondarev AD; Department of Pharmacology, Institute of Pharmacy, I. M. Sechenov First Moscow State Medical University , Moscow, Russia.
Attwood MM; Department Of Neuroscience, Functional Pharmacology, Uppsala University , Uppsala, Sweden.
Jonsson J; Department Of Neuroscience, Functional Pharmacology, Uppsala University , Uppsala, Sweden.
Chubarev VN; Department Of Neuroscience, Functional Pharmacology, Uppsala University , Uppsala, Sweden.
Tarasov VV; Department of Pharmacology, Institute of Pharmacy, I. M. Sechenov First Moscow State Medical University , Moscow, Russia.
Schiöth HB; Department of Pharmacology, Institute of Pharmacy, I. M. Sechenov First Moscow State Medical University , Moscow, Russia.

Expert Opin Drug Discov ; 15(11): 1291-1307, 2020 11.

Article em En | MEDLINE | ID: mdl-32648789

Assuntos

Desenvolvimento de Medicamentos; Descoberta de Drogas; Receptores Acoplados a Proteínas G/efeitos dos fármacos; Animais; Humanos; Ligantes; Terapia de Alvo Molecular; Receptores Acoplados a Proteínas G/metabolismo; Relação Estrutura-Atividade

Palavras-chave

3-α-acetoxydihydrodeoxygedunin; Adhesion GPCR; dihydromunduletone; drug discovery; synaptamide; tethered peptide

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Acoplados a Proteínas G / Descoberta de Drogas / Desenvolvimento de Medicamentos Limite: Animals / Humans Idioma: En Revista: Expert Opin Drug Discov Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Federação Russa

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