Heat- or light-induced acylarylation of unactivated alkenes towards 3-(α-acyl) indolines.
Org Biomol Chem
; 18(29): 5660-5665, 2020 08 07.
Article
em En
| MEDLINE
| ID: mdl-32661537
ABSTRACT
A heat- or photoredox/iron dual catalysis-enabled dehydrogenative acylarylation of N-allyl anilines leading to 2-substituted 3-(α-acyl) indolines with a quaternary stereogenic center is presented, with unactivated alkenic bonds as radical acceptors and simple aldehydes as radical precursors. This reaction features high yields, a broad substrate scope, and a great exo selectivity, and gram-scale syntheses could be readily carried out.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2020
Tipo de documento:
Article