Toxoplasma Mechanisms for Delivery of Proteins and Uptake of Nutrients Across the Host-Pathogen Interface.
Annu Rev Microbiol
; 74: 567-586, 2020 09 08.
Article
em En
| MEDLINE
| ID: mdl-32680452
ABSTRACT
Many intracellular pathogens, including the protozoan parasite Toxoplasma gondii, live inside a vacuole that resides in the host cytosol. Vacuolar residence provides these pathogens with a defined niche for replication and protection from detection by host cytosolic pattern recognition receptors. However, the limiting membrane of the vacuole, which constitutes the host-pathogen interface, is also a barrier for pathogen effectors to reach the host cytosol and for the acquisition of host-derived nutrients. This review provides an update on the specialized secretion and trafficking systems used by Toxoplasma to overcome the barrier of the parasitophorous vacuole membrane and thereby allow the delivery of proteins into the host cell and the acquisition of host-derived nutrients.
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Base de dados:
MEDLINE
Assunto principal:
Toxoplasma
/
Proteínas de Protozoários
/
Nutrientes
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Citosol
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Interações Hospedeiro-Parasita
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Microbiol
Ano de publicação:
2020
Tipo de documento:
Article