Visible light photoredox alkylazidation of alkenes with sodium azide and heteroarenium salts: entry to azido-containing 1,4-dihydropyridines.
Chem Commun (Camb)
; 56(66): 9549-9552, 2020 Aug 19.
Article
em En
| MEDLINE
| ID: mdl-32691800
ABSTRACT
A three-component alkene alkylazidation using sodium azide as the azido resource and heteroarenium salts as functionalized alkyl reagents for producing highly valuable 2-azido-1-(1,4-dihydropyridin-4-yl)-ethanes is described. This reaction allows the incorporation of both an azido group and a 1,4-dihydropyridin-4-yl group across C[double bond, length as m-dash]C bonds to construct two new bonds in a single reaction step, and represents a practical and mechanistically distinct alternative that harnesses an electrophilic heteroarenium ion to accomplish the alkene difunctionalization reaction.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2020
Tipo de documento:
Article