Lactic Acidosis Secondary to Thiamin Deficiency Following Autologous Stem Cell Transplantation.
Nutr Clin Pract
; 36(2): 414-418, 2021 Apr.
Article
em En
| MEDLINE
| ID: mdl-32700422
ABSTRACT
A 22-month-old female with high-risk neuroblastoma completed 5 cycles of chemotherapy then underwent high-dose chemotherapy with autologous stem cell rescue (ASCR). Parenteral nutrition was administered from day +2 following ASCR, as she was unable to tolerate nasogastric feeds because of grade IV mucositis and vomiting. On day +12, she developed worsening metabolic acidosis with above reportable levels of lactic acid. Given the patient's well clinical appearance and paucity of evidence of end-organ dysfunction on physical examination and on laboratory studies, there was high suspicion that the patient's lactic acidosis did not result from tissue hypoxia and was, in fact, a type B lactic acidosis. Thiamin was empirically administered, with rapid improvement in lactic acidosis. Thiamin deficiency was later confirmed by laboratory studies drawn prior to thiamin administration.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Deficiência de Tiamina
/
Acidose Láctica
/
Transplante de Células-Tronco Hematopoéticas
Tipo de estudo:
Etiology_studies
Limite:
Female
/
Humans
/
Infant
Idioma:
En
Revista:
Nutr Clin Pract
Assunto da revista:
CIENCIAS DA NUTRICAO
/
ENFERMAGEM
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos