Four pleiotropic loci associated with fat mass and lean mass.
Int J Obes (Lond)
; 44(10): 2113-2123, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-32719433
ABSTRACT
BACKGROUND:
Fat mass and lean mass are two biggest components of body mass. Both fat mass and lean mass are under strong genetic determinants and are correlated.METHODS:
We performed a bivariate genome-wide association meta-analysis of (lean adjusted) leg fat mass and (fat adjusted) leg lean mass in 12,517 subjects from 6 samples, and followed by in silico replication in large-scale UK biobank cohort sample (N = 370 097).RESULTS:
We identified four loci that were significant at the genome-wide significance (GWS, α = 5.0 × 10-8) level at the discovery meta-analysis, and successfully replicated in the replication sample 2q36.3 (rs1024137, pdiscovery = 3.32 × 10-8, preplication = 4.07 × 10-13), 5q13.1 (rs4976033, pdiscovery = 1.93 × 10-9, preplication = 6.35 × 10-7), 12q24.31 (rs4765528, pdiscovery = 7.19 × 10-12, preplication = 1.88 × 10-11) and 18q21.32 (rs371326986, pdiscovery = 9.04 × 10-9, preplication = 2.35 × 10-95). The above four pleiotropic loci may play a pleiotropic role for fat mass and lean mass development.CONCLUSIONS:
Our findings further enhance the understanding of the genetic association between fat mass and lean mass and provide a new theoretical basis for their understanding.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Adiposidade
/
Estudo de Associação Genômica Ampla
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Pleiotropia Genética
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
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Systematic_reviews
Limite:
Adult
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Aged
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Humans
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Int J Obes (Lond)
Assunto da revista:
METABOLISMO
Ano de publicação:
2020
Tipo de documento:
Article