Glycogen Synthase Kinase-3 Signaling in Acute Kidney Injury.
Nephron
; 144(12): 609-612, 2020.
Article
em En
| MEDLINE
| ID: mdl-32726778
ABSTRACT
Acute kidney injury (AKI) is a common clinical syndrome that involves renal tubular epithelial cell death and leads to acute decline in renal function. Improper tubular regeneration following AKI often leads to CKD. We discuss the role of a serine/threonine protein kinase called glycogen synthase kinase-3 (GSK3) in renal tubular injury and renal fibrosis. We also highlight the importance of GSK3 as a potential drug target in AKI patients and molecular mechanisms promoting tissue regeneration.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Quinase 3 da Glicogênio Sintase
/
Injúria Renal Aguda
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nephron
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos