Cutaneous and Pulmonary Mucormycosis in Rag1- and Il2rg-deficient Rats.
Comp Med
; 70(4): 390-395, 2020 08 01.
Article
em En
| MEDLINE
| ID: mdl-32736665
ABSTRACT
Immunodeficient rats are valuable in transplantation studies, but are vulnerable to infection from opportunistic organisms such as fungi. Immunodeficient Rag1- and Il2rg-deficient (RRG) rats housed at our institution presented with dark, proliferative, keratinized dermal growths. Histologic and PCR results indicated that the predominant organism associated with these lesions was fungus from the family Mucoraceae, mostly of the genus Rhizopus. The Mucoraceae family of fungi are environmental saprophytes and are often found in rodent bedding. These fungi can cause invasive opportunistic infections in immunosuppressed humans and animals. We discuss husbandry practices for immunosuppressed rodents with a focus on controlling fungal contaminants.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Oportunistas
/
Mucormicose
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Comp Med
Assunto da revista:
MEDICINA
/
MEDICINA VETERINARIA
Ano de publicação:
2020
Tipo de documento:
Article