Structure-Activity Relationship of Anti-malarial Allylpyrocatechol Isolated from Piper betle.
Chem Pharm Bull (Tokyo)
; 68(8): 784-790, 2020.
Article
em En
| MEDLINE
| ID: mdl-32741921
ABSTRACT
Malaria disease remains a serious worldwide health problem. In South-East Asia, one of the malaria infection "hot-spots," medicinal plants such as Piper betle have traditionally been used for the treatment of malaria, and allylpyrocatechol (1), a constituent of P. betle, has been shown to exhibit anti-malarial activities. In this study, we verified that 1 showed in vivo anti-malarial activity through not only intraperitoneal (i.p.) but also peroral (p.o.) administration. Additionally, some analogs of 1 were synthesized and the structure-activity relationship was analyzed to disclose the crucial sub-structures for the potent activity.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Catecóis
/
Piper betle
/
Antimaláricos
Limite:
Animals
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Ano de publicação:
2020
Tipo de documento:
Article