Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails.

Mattijssen, Sandy; Iben, James R; Li, Tianwei; Coon, Steven L; Maraia, Richard J

Mattijssen, Sandy; Iben, James R; Li, Tianwei; Coon, Steven L; Maraia, Richard J.

Afiliação

Mattijssen S; Intramural Research Program, <italic>Eunice Kennedy Shriver</italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Iben JR; Intramural Research Program, <italic>Eunice Kennedy Shriver</italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Li T; Intramural Research Program, <italic>Eunice Kennedy Shriver</italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Coon SL; Intramural Research Program, <italic>Eunice Kennedy Shriver</italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Maraia RJ; Intramural Research Program, <italic>Eunice Kennedy Shriver</italic> National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.

Elife ; 92020 08 03.

Article em En | MEDLINE | ID: mdl-32744499

Assuntos

Adenina/metabolismo; Autoantígenos/metabolismo; Poli A/metabolismo; Estabilidade de RNA; RNA Mensageiro/metabolismo; Ribonucleoproteínas/metabolismo; Animais; Linhagem Celular; Feminino; Perfilação da Expressão Gênica; Técnicas de Inativação de Genes; Células HEK293; Humanos; Camundongos; Proteínas de Ligação a Poli(A)/metabolismo; Análise de Sequência de RNA/métodos; Imagem Individual de Molécula; Antígeno SS-B

Palavras-chave

PABP; biochemistry; chemical biology; deadenylation; human; poly(A); polyA tail

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poli A / Ribonucleoproteínas / Autoantígenos / RNA Mensageiro / Adenina / Estabilidade de RNA Limite: Animals / Female / Humans Idioma: En Revista: Elife Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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