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Delineation of molecular determinants for FR900359 inhibition of Gq/11 unlocks inhibition of Gαs.
Boesgaard, Michael W; Harpsøe, Kasper; Malmberg, Michelle; Underwood, Christina R; Inoue, Asuka; Mathiesen, Jesper M; König, Gabriele M; Kostenis, Evi; Gloriam, David E; Bräuner-Osborne, Hans.
Afiliação
  • Boesgaard MW; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Harpsøe K; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Malmberg M; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Underwood CR; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Inoue A; Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan.
  • Mathiesen JM; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • König GM; Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
  • Kostenis E; Molecular, Cellular, and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
  • Gloriam DE; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: hbo@sund.ku.dk.
  • Bräuner-Osborne H; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: david.gloriam@sund.ku.dk.
J Biol Chem ; 295(40): 13850-13861, 2020 10 02.
Article em En | MEDLINE | ID: mdl-32753482
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Subunidades alfa de Proteínas de Ligação ao GTP / Subunidades alfa Gq-G11 de Proteínas de Ligação ao GTP / Depsipeptídeos / Mutação Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Dinamarca
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Subunidades alfa de Proteínas de Ligação ao GTP / Subunidades alfa Gq-G11 de Proteínas de Ligação ao GTP / Depsipeptídeos / Mutação Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Dinamarca