The Effects of Antipsychotics on the Synaptic Plasticity Gene <i>Homer1a</i> Depend on a Combination of Their Receptor Profile, Dose, Duration of Treatment, and Brain Regions Targeted.

Iasevoli, Felice; Buonaguro, Elisabetta Filomena; Avagliano, Camilla; Barone, Annarita; Eramo, Anna; Vellucci, Licia; de Bartolomeis, Andrea

The Effects of Antipsychotics on the Synaptic Plasticity Gene Homer1a Depend on a Combination of Their Receptor Profile, Dose, Duration of Treatment, and Brain Regions Targeted.

Iasevoli, Felice; Buonaguro, Elisabetta Filomena; Avagliano, Camilla; Barone, Annarita; Eramo, Anna; Vellucci, Licia; de Bartolomeis, Andrea.

Afiliação

Iasevoli F; Laboratory of Molecular and Translational Psychiatry and Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science, and Odontostomatology, University of Naples Federico II, 80131 Napoli, Italy.
Buonaguro EF; Laboratory of Molecular and Translational Psychiatry and Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science, and Odontostomatology, University of Naples Federico II, 80131 Napoli, Italy.
Avagliano C; Laboratory of Molecular and Translational Psychiatry and Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science, and Odontostomatology, University of Naples Federico II, 80131 Napoli, Italy.
Barone A; Laboratory of Molecular and Translational Psychiatry and Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science, and Odontostomatology, University of Naples Federico II, 80131 Napoli, Italy.
Eramo A; Lundbeck LLC, Deerfield, IL 60015, USA.
Vellucci L; Laboratory of Molecular and Translational Psychiatry and Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science, and Odontostomatology, University of Naples Federico II, 80131 Napoli, Italy.
de Bartolomeis A; Laboratory of Molecular and Translational Psychiatry and Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science, and Odontostomatology, University of Naples Federico II, 80131 Napoli, Italy.

Int J Mol Sci ; 21(15)2020 Aug 03.

Article em En | MEDLINE | ID: mdl-32756473

Assuntos

Antipsicóticos/farmacologia; Encéfalo/efeitos dos fármacos; Proteínas de Arcabouço Homer/genética; Plasticidade Neuronal/efeitos dos fármacos; Animais; Antipsicóticos/efeitos adversos; Encéfalo/metabolismo; Mapeamento Encefálico; Dibenzocicloeptenos; Relação Dose-Resposta a Droga; Duração da Terapia; Haloperidol/farmacologia; Compostos Heterocíclicos de 4 ou mais Anéis/farmacologia; Humanos; Hibridização In Situ; Modelos Animais; Plasticidade Neuronal/genética; Olanzapina/farmacologia; Densidade Pós-Sináptica/efeitos dos fármacos; Densidade Pós-Sináptica/genética; Ratos; Distribuição Tecidual/efeitos dos fármacos

Palavras-chave

asenapine; dopamine; gene expression; glutamate; haloperidol; olanzapine; psychosis; synaptic plasticity; treatment resistant schizophrenia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antipsicóticos / Encéfalo / Proteínas de Arcabouço Homer / Plasticidade Neuronal Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália

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