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Design, synthesis and structure-activity relationship study of piperazinone-containing thieno[3,2-d]pyrimidine derivatives as new PI3Kδ inhibitors.
Wang, Ning-Yu; Zuo, Wei-Qiong; Hu, Rong; Wang, Wan-Li; Zhu, Yong-Xia; Xu, Ying; Yu, Luo-Ting; Liu, Zhi-Hao.
Afiliação
  • Wang NY; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China. Electronic address: wangny-swjtu@swjtu.edu.cn.
  • Zuo WQ; Lab of Medicinal Chemistry, Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China.
  • Hu R; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China.
  • Wang WL; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China.
  • Zhu YX; Lab of Medicinal Chemistry, Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China.
  • Xu Y; Lab of Medicinal Chemistry, Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China.
  • Yu LT; Lab of Medicinal Chemistry, Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China.
  • Liu ZH; Lab of Medicinal Chemistry, Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China. Electronic address: liuzhihao@scu.edu.cn.
Bioorg Med Chem Lett ; 30(20): 127479, 2020 10 15.
Article em En | MEDLINE | ID: mdl-32784091
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Pirimidinas / Desenho de Fármacos / Classe I de Fosfatidilinositol 3-Quinases / Inibidores de Fosfoinositídeo-3 Quinase / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Pirimidinas / Desenho de Fármacos / Classe I de Fosfatidilinositol 3-Quinases / Inibidores de Fosfoinositídeo-3 Quinase / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article