How a B family DNA polymerase has been evolved to copy RNA.

Choi, Woo Suk; He, Peng; Pothukuchy, Arti; Gollihar, Jimmy; Ellington, Andrew D; Yang, Wei

Choi, Woo Suk; He, Peng; Pothukuchy, Arti; Gollihar, Jimmy; Ellington, Andrew D; Yang, Wei.

Afiliação

Choi WS; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892.
He P; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892.
Pothukuchy A; Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712.
Gollihar J; Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712.
Ellington AD; Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712.
Yang W; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892; wei.yang@nih.gov.

Proc Natl Acad Sci U S A ; 117(35): 21274-21280, 2020 09 01.

Article em En | MEDLINE | ID: mdl-32817521

Assuntos

Evolução Molecular; DNA Polimerase Dirigida por RNA/genética; DNA Polimerase Dirigida por RNA/metabolismo; RNA/biossíntese; Substituição de Aminoácidos; Domínio Catalítico; Cristalografia por Raios X; Conformação Proteica; DNA Polimerase Dirigida por RNA/química

Palavras-chave

3' to 5' exonuclease; Thumb domain; proofreading; reverse transcription

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA / DNA Polimerase Dirigida por RNA / Evolução Molecular Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article

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