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A new indolizinium alkaloid from marine-derived Streptomyces sp. HNA39.
Cheng, Xiang-Wei; Li, Jia-Qi; Jiang, Yong-Jun; Liu, Hua-Zhang; Huo, Chao.
Afiliação
  • Cheng XW; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
  • Li JQ; Experiment Center, Zhejiang Police College, Hangzhou 310053, China.
  • Jiang YJ; Institute of Marine Biology and Pharmacology, Ocean College, Zhejiang University, Zhoushan 316021, China.
  • Liu HZ; School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China.
  • Huo C; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
J Asian Nat Prod Res ; 23(9): 913-918, 2021 Sep.
Article em En | MEDLINE | ID: mdl-32819162
A new indolizinium alkaloid, named as cyclizidine J (1), was identified from Gause's liquid fermentation of marine-derived Streptomyces sp. HNA39. Its structure was elucidated by extensive NMR spectroscopic methods, HRESIMS data, and ECD calculations. To our best knowledge, compound 1 was a unique cyclizidine-type alkaloid that contain a chlorine atom substituted at position C-8. Unfortunately, biological evaluation of 1 exhibited no active against PC-3 cancer cell line, BRD4, and ROCK2 protein kinase.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptomyces / Alcaloides Tipo de estudo: Prognostic_studies Idioma: En Revista: J Asian Nat Prod Res Assunto da revista: BOTANICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptomyces / Alcaloides Tipo de estudo: Prognostic_studies Idioma: En Revista: J Asian Nat Prod Res Assunto da revista: BOTANICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China