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MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity.
Grunblatt, Eli; Wu, Nan; Zhang, Huajia; Liu, Xiaoli; Norton, Justin P; Ohol, Yamini; Leger, Paul; Hiatt, Joseph B; Eastwood, Emily C; Thomas, Rhiana; Ibrahim, Ali H; Jia, Deshui; Basom, Ryan; Eaton, Keith D; Martins, Renato; Houghton, A McGarry; MacPherson, David.
Afiliação
  • Grunblatt E; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Wu N; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Zhang H; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Liu X; Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Norton JP; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Ohol Y; Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou City, Henan Province 450008, China.
  • Leger P; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Hiatt JB; RAPT Therapeutics, Inc., South San Francisco, California 94080, USA.
  • Eastwood EC; RAPT Therapeutics, Inc., South San Francisco, California 94080, USA.
  • Thomas R; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Ibrahim AH; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Jia D; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Basom R; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Eaton KD; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Martins R; Genomics and Bioinformatics Shared Resource, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Houghton AM; Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, Washington 98195, USA.
  • MacPherson D; Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, Washington 98195, USA.
Genes Dev ; 34(17-18): 1210-1226, 2020 09 01.
Article em En | MEDLINE | ID: mdl-32820040
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistencia a Medicamentos Antineoplásicos / Proteína Proto-Oncogênica N-Myc / Peptidase 7 Específica de Ubiquitina / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Genes Dev Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistencia a Medicamentos Antineoplásicos / Proteína Proto-Oncogênica N-Myc / Peptidase 7 Específica de Ubiquitina / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Genes Dev Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos