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Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions.
Fahed, Akl C; Wang, Minxian; Homburger, Julian R; Patel, Aniruddh P; Bick, Alexander G; Neben, Cynthia L; Lai, Carmen; Brockman, Deanna; Philippakis, Anthony; Ellinor, Patrick T; Cassa, Christopher A; Lebo, Matthew; Ng, Kenney; Lander, Eric S; Zhou, Alicia Y; Kathiresan, Sekar; Khera, Amit V.
Afiliação
  • Fahed AC; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Wang M; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Homburger JR; Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Patel AP; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Bick AG; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Neben CL; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Lai C; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Brockman D; Color Genomics, Burlingame, CA, USA.
  • Philippakis A; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Ellinor PT; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Cassa CA; Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Lebo M; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Ng K; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Lander ES; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Zhou AY; Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Kathiresan S; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Khera AV; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Nat Commun ; 11(1): 3635, 2020 08 20.
Article em En | MEDLINE | ID: mdl-32820175
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Penetrância / Predisposição Genética para Doença / Herança Multifatorial Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Penetrância / Predisposição Genética para Doença / Herança Multifatorial Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos