Potentiation of antibiotic activity by chalcone (E)-1-(4'-aminophenyl)-3-(furan-2-yl)-prop-2-en-1-one against gram-positive and gram-negative MDR strains.
Microb Pathog
; 148: 104453, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-32828903
ABSTRACT
Chalcones are α,ß-unsaturated ketones containing the 1,3-diarylprop-2-en-1-one framework. This study aims to evaluate the potentiation of antibacterial activity by the chalcone (E)-1-(4-aminophenyl)-3-(furan-2-yl)-prop-2-en-1-one (C13H11NO2), hereafter named AFPO, against multi-resistant strains of Staphylococcus aureus and Escherichia coli. AFPO was synthesized using the Claisen-Schmidt condensation reaction, and the molecular structure was confirmed by nuclear magnetic resonance (NMR). The antibacterial and potentiating properties of AFPO were evaluated by measuring the minimum inhibitory concentration (MIC) using microdilution plates. The AFPO MIC was 1024 µg/mL for the S. aureus 10 strain, revealing synergy in combination with the following antibiotics penicillin, norfloxacin, ampicillin/sulbactam, and gentamicin. The AFPO MIC was 256 µg/mL for the E. coli 06 strain, and synergy was observed with norfloxacin, gentamicin, and penicillin. The potentiation of antibacterial activity by AFPO was observed against the strains of S. aureus 10 and E. coli 06.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Chalcona
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Proteínas de Escherichia coli
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Simportadores
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Chalconas
Idioma:
En
Revista:
Microb Pathog
Assunto da revista:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Brasil