Outbreak of hepatitis A in a post-vaccination era: High rate of co-infection with sexually transmitted diseases.
Ann Hepatol
; 19(6): 641-644, 2020.
Article
em En
| MEDLINE
| ID: mdl-32835862
ABSTRACT
INTRODUCTION AND OBJECTIVES:
After hepatitis A (HAV) mandatory immunization in 2005 in Argentina, the incidence of HAV declined drastically. However, several new autochthonous cases of HAV have been reported since 2017. We aimed to evaluate the clinical and epidemiological characteristics and possible transmission routes of affected patients. PATIENTS OR MATERIALS ANDMETHODS:
We performed a cross-sectional study of patients residing in Argentina with acute hepatitis A between 30.06.2017 and 31.12.2018.RESULTS:
66 cases of HAV were registered. Fifty-six patients (86%) were males, with a mean age of 34⯱â¯12 years old. The most likely routes of transmission were sexual intercourse of men with men, reported by 31 patients. Additionally, 23% and 26% of patients tested positive for HIV and syphilis, respectively. In total, 35% of patients required hospitalization. When assessing outcomes, 79% had a mild presentation and 21% had a severe/fulminant presentation one patient underwent liver transplantation, and one patient died.CONCLUSIONS:
Our study describes that during the study period, HAV infection affected predominantly young adults, particularly men who have sex with men. An elevated proportion of them was diagnosed with a concomitant sexually transmitted disease, and several patients had a severe presentation of the disease.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Infecções Sexualmente Transmissíveis
/
Surtos de Doenças
/
Coinfecção
/
Hepatite A
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do sul
/
Argentina
Idioma:
En
Revista:
Ann Hepatol
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Argentina