Stability of 0.5% Glucose-Containing Balanced Electrolyte Solutions for Patients on Ketogenic Diets: A Laboratory Study.
Neuropediatrics
; 51(6): 397-400, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-32842160
ABSTRACT
PURPOSE:
Ketogenic diets (KDs) are used to treat epilepsies resistant to pharmacotherapy or some inborn errors of metabolism. For prolonged anesthesia, use of balanced electrolyte solutions (BESs) supplemented with 0.5% glucose has been advocated to maintain ketosis while preventing hypoglycemia. Unfortunately, there is no BES containing 0.5% glucose available from pharmacies. In a laboratory study, we investigated the physical and chemical stability of different BES mixtures containing 0.5% glucose.METHODS:
In total, six approaches were chosen to create a BES with 0.5% glucose three different glucose-free BESs were supplemented with glucose. Additionally, commercially available BES containing 1% glucose was diluted with three different glucose-free BESs to obtain a solution containing 0.5% glucose. Turbidity, pH, electrical conductivity, and macroscopic appearance of these solutions were measured immediately, at 24 hours, and after 7 days, and were compared with the original BES.RESULTS:
Turbidity, pH, and electrical conductivity, as well as macroscopic appearance did not exceed the changes of the controls.CONCLUSIONS:
No signs of incompatibility reactions could be observed in a 1-week time period. Our study supports the stability of the examined BES containing 0.5% glucose for prolonged anesthesia in patients on KD. Clinical studies are needed to evaluate if BES containing 0.5% glucose is superior in patients on KDs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Eletrólitos
/
Dieta Cetogênica
/
Glucose
Limite:
Humans
Idioma:
En
Revista:
Neuropediatrics
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Alemanha