Immune System Remodelling by Prenatal Betamethasone: Effects on ß-Cells and Type 1 Diabetes.
Front Endocrinol (Lausanne)
; 11: 540, 2020.
Article
em En
| MEDLINE
| ID: mdl-32849311
ABSTRACT
Type 1 diabetes (T1D) is a multifactorial disease of unknown aetiology. Studies focusing on environment-related prenatal changes, which might have an influence on the development of T1D, are still missing. Drugs, such as betamethasone, are used during this critical period without exploring possible effects later in life. Betamethasone can interact with the development and function of the two main players in T1D, the immune system and the pancreatic ß-cells. Short-term or persistent changes in any of these two players may influence the initiation of the autoimmune reaction against ß-cells. In this review, we focus on the ability of betamethasone to induce alterations in the immune system, impairing the recognition of autoantigens. At the same time, betamethasone affects ß-cell gene expression and apoptosis rate, reducing the danger signals that will attract unwanted attention from the immune system. These effects may synergise to hinder the autoimmune attack. In this review, we compile scattered evidence to provide a better understanding of the basic relationship between betamethasone and T1D, laying the foundation for future studies on human cohorts that will help to fully grasp the role of betamethasone in the development of T1D.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Betametasona
/
Diabetes Mellitus Tipo 1
/
Células Secretoras de Insulina
/
Feto
/
Sistema Imunitário
/
Anti-Inflamatórios
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Front Endocrinol (Lausanne)
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Espanha