Revisiting the role of acids and hydrogen bond acceptors in enamine formation.
Org Biomol Chem
; 18(35): 6849-6852, 2020 Sep 21.
Article
em En
| MEDLINE
| ID: mdl-32852003
ABSTRACT
A systematic investigation into the effects of acids and hydrogen bond acceptors on the reaction rates and equilibria of enamine formation is reported. Acids can accelerate the reaction but do not change the reaction equilibria. In comparison, hydrogen bond acceptors facilitate the enamine formation via their strong hydrogen bonding interaction with the water generated in the reaction.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos