Brief Report: Increased Cotinine Concentrations are Associated With Reduced Expression of Cathelicidin (LL-37) and NOD-2 in Alveolar Macrophages of PLWH Who Smoke.
J Acquir Immune Defic Syndr
; 85(5): 670-673, 2020 12 15.
Article
em En
| MEDLINE
| ID: mdl-32852363
ABSTRACT
There is a strong link between cigarette smoking and pulmonary complications among people living with HIV. However, the effects of smoking on the local lung immune environment in this population remain unclear. Bronchoalveolar lavage and saliva were collected from HIV-infected smokers involved in a prospective study investigating alveolar macrophage expression of host defense molecules. Salivary cotinine concentrations were inversely related to expression of the immune cell receptor nucleotide-binding oligomerization domain-2 and the cathelicidin antimicrobial peptide LL-37. The negative correlation between salivary cotinine and LL-37 was particularly strong. Our study provides insight into how nicotine may adversely affect lung innate immunity in HIV.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fumar
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Infecções por HIV
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Macrófagos Alveolares
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Cotinina
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Peptídeos Catiônicos Antimicrobianos
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Proteína Adaptadora de Sinalização NOD2
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Female
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Humans
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Male
Idioma:
En
Revista:
J Acquir Immune Defic Syndr
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
2020
Tipo de documento:
Article