Celiac disease and reproductive failures: An update on pathogenic mechanisms.
Am J Reprod Immunol
; 85(4): e13334, 2021 04.
Article
em En
| MEDLINE
| ID: mdl-32865829
ABSTRACT
Celiac disease (CD) is an autoimmune disorder that occurs in genetically predisposed people in which the ingestion of gluten leads to damage in the small intestine that clinically presents with malabsorption-related symptoms. CD can also be the underlying cause of several non-gastrointestinal symptoms. This review summarizes evidence on the relationship between CD and gynecological/obstetric disorders like reproductive failures. Although much has been reported on such a linkage, the pathogenic mechanisms remain unclear, especially those underlying extra-gastrointestinal clinical manifestations. Studies conducted on celiac subjects presenting gynecological/obstetric disorders have pointed to intestinal malabsorption, coagulation alterations, immune-mediated tissue damage, and endometrial inflammation as the main responsible pathogenic mechanisms. Currently, however, the knowledge of such mechanisms is insufficient, and further studies are needed to gain a more thorough understanding of the matter.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Resultado da Gravidez
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Doença Celíaca
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Aborto Habitual
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Retardo do Crescimento Fetal
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Infertilidade Feminina
Limite:
Animals
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Am J Reprod Immunol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Itália