Trichothecrotocins D-L, Antifungal Agents from a Potato-Associated Trichothecium crotocinigenum.
J Nat Prod
; 83(9): 2756-2763, 2020 09 25.
Article
em En
| MEDLINE
| ID: mdl-32870001
ABSTRACT
Seven new merosesquiterpenoids, trichothecrotocins D-J (1-7), two new trichothecene sesquiterpenoids, trichothecrotocins K (12) and L (13), and six known compounds (8-11, 14, and 15), were isolated from a potato-associated fungus, Trichothecium crotocinigenum. Compounds 5 and 6 were racemates which were further separated as pure enantiomers. Structures together with absolute configurations were established by extensive spectroscopic analysis, as well as quantum chemistry calculations on ECD and optical rotations. Compounds 1-4 are rare meroterpenoids featuring a seco-phenyl group, while 1 and 2 possessed a novel 6-6/5 fused ring system. Compounds 1-4, 8, 11, and 12 showed antifungal activity against four plant pathogens with MIC values of 8-128 µg/mL. It is suggested that the meroterpenoids produced by T. crotocinigenum may play an important role in the antifungal property of the fungus, thereby protecting the host plant, i.e., potato.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Solanum tuberosum
/
Hypocreales
/
Antifúngicos
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2020
Tipo de documento:
Article