Plasma factors influencing prostacyclin-like activity in patients with diabetic microangiopathy.
Prostaglandins Leukot Essent Fatty Acids
; 31(3): 107-11, 1988 Mar.
Article
em En
| MEDLINE
| ID: mdl-3287394
ABSTRACT
Plasma factors influencing PGI2-like activity in 19 patients with diabetes mellitus /Dm/ and 17 controls were studied through a comparison with the signs of retinal and glomerular angiopathy. The plasma PGI2 supporting activity /PSA/ was lower in 15 Dm cases than in the controls. Inhibitory activity against PGI2 production was detected in 6 patients. In the cases of more serious retinopathy associated with glomerulopathy, a significantly lower level of PSA was observed than in patients with mild retinopathy without glomerular diseases. The plasma concentrations of total and LDL-cholesterol were significantly higher, while the level of HDL-cholesterol was lower than in the controls. There was a positive correlation between PSA and HDL-cholesterol values and a negative correlation between PSA and LDL-cholesterol levels, which relates to an inhibitory effect of LDL and a protective role of HDL in PGI2 synthesis.
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Base de dados:
MEDLINE
Assunto principal:
Epoprostenol
/
Angiopatias Diabéticas
Limite:
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Prostaglandins Leukot Essent Fatty Acids
Assunto da revista:
ENDOCRINOLOGIA
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Hungria