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Dimeric Tetrahydroanthracene Regioisomers and Their Monomeric Precursor Produced by Streptomyces fumigatiscleroticus HDN10255.
Wang, Junxiao; Wang, Haotian; Sun, Chunxiao; Li, Fenge; Wu, Yingqiang; Zhang, Guojian; Gu, Qianqun; Zhu, Tianjiao; Li, Dehai; Che, Qian.
Afiliação
  • Wang J; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • Wang H; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • Sun C; Faculty of Pharmacy, Bengbu Medical College, Bengbu 233030, People's Republic of China.
  • Li F; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • Wu Y; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • Zhang G; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • Gu Q; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • Zhu T; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, People's Republic of China.
  • Li D; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • Che Q; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
J Nat Prod ; 83(9): 2797-2802, 2020 09 25.
Article em En | MEDLINE | ID: mdl-32880456
ABSTRACT
Four new tetrahydroanthracene derivatives (1, 3-5) and a known antibiotic, A-39183A (2), were discovered from the marine-sponge-derived actinomycete Streptomyces fumigatiscleroticus HDN10255. Their structures including absolute configurations were elucidated based upon MS and NMR spectroscopic data, ECD calculations, and biogenetic considerations. Compounds 2 and 4 showed considerable cytotoxicity with the best IC50 value of 1.8 µM against HeLa cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptomyces / Antibióticos Antineoplásicos Limite: Animals / Humans Idioma: En Revista: J Nat Prod Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptomyces / Antibióticos Antineoplásicos Limite: Animals / Humans Idioma: En Revista: J Nat Prod Ano de publicação: 2020 Tipo de documento: Article