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Design, synthesis, molecular modeling, in vivo studies and anticancer activity evaluation of new phthalazine derivatives as potential DNA intercalators and topoisomerase II inhibitors.
El-Helby, Abdel-Ghany A; Sakr, Helmy; Ayyad, Rezk R; Mahdy, Hazem A; Khalifa, Mohamed M; Belal, Amany; Rashed, Mahmoud; El-Sharkawy, Abdou; Metwaly, Ahmed M; Elhendawy, Mostafa A; Radwan, Mohamed M; ElSohly, Mahmoud A; Eissa, Ibrahim H.
Afiliação
  • El-Helby AA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
  • Sakr H; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
  • Ayyad RR; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: rezek_ayad@yahoo.com.
  • Mahdy HA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: hazem_hady2001@azhar.edu.eg.
  • Khalifa MM; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
  • Belal A; Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
  • Rashed M; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
  • El-Sharkawy A; Department of Anatomy, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; Department of Anatomy, College of Medicine, Jouf University, Saudi Arabia.
  • Metwaly AM; Pharmacognosy Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
  • Elhendawy MA; Department of Agriculture Chemistry, Faculty of Agriculture, Damietta University, Damietta, Egypt.
  • Radwan MM; National Center for Natural Products Research, University of Mississippi, MS 38677, USA; Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
  • ElSohly MA; National Center for Natural Products Research, University of Mississippi, MS 38677, USA; Department of Pharmaceutics and Drug Delivery, University of Mississippi, University, MS 38677, USA.
  • Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: Ibrahimeissa@azhar.edu.eg.
Bioorg Chem ; 103: 104233, 2020 10.
Article em En | MEDLINE | ID: mdl-32882440
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ftalazinas / Inibidores da Topoisomerase II / Substâncias Intercalantes / Neoplasias / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Egito
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ftalazinas / Inibidores da Topoisomerase II / Substâncias Intercalantes / Neoplasias / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Egito