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miRNA-Based Therapies in B Cell Non-Hodgkin Lymphoma.
Fuertes, Teresa; Ramiro, Almudena R; de Yebenes, Virginia G.
Afiliação
  • Fuertes T; Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
  • Ramiro AR; Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain. Electronic address: aramiro@cnic.es.
  • de Yebenes VG; Universidad Complutense de Madrid School of Medicine, Department of Immunology, Ophthalmology and ENT, 12 de Octubre Health Research Institute (imas12), Madrid, Spain. Electronic address: vgarciay@ucm.es.
Trends Immunol ; 41(10): 932-947, 2020 10.
Article em En | MEDLINE | ID: mdl-32888820
ABSTRACT
Non-Hodgkin lymphoma (NHL) is a diverse class of hematological cancers, many of which arise from germinal center (GC)-experienced B cells. Thus GCs, the sites of antibody affinity maturation triggered during immune responses, also provide an environment that facilitates B cell oncogenic transformation. miRNAs provide attractive and mechanistically different strategies to treat these malignancies based on their potential for simultaneous modulation of multiple targets. Here, we discuss the scientific rationale for miRNA-based therapeutics in B cell neoplasias and review recent advances that may help establish a basis for novel candidate miRNA-based therapies for B cell-NHL (B-NHL).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfoma não Hodgkin / MicroRNAs Limite: Humans Idioma: En Revista: Trends Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfoma não Hodgkin / MicroRNAs Limite: Humans Idioma: En Revista: Trends Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha