Novel inhibition mechanism of carbapenems on the ACC-1 class C ß-lactamase.

Bae, Da-Woon; Jung, Ye-Eun; Jeong, Bo-Gyeong; Cha, Sun-Shin

Bae, Da-Woon; Jung, Ye-Eun; Jeong, Bo-Gyeong; Cha, Sun-Shin.

Afiliação

Bae DW; Department of Chemistry & Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea.
Jung YE; Department of Chemistry & Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea.
Jeong BG; Department of Chemistry & Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea.
Cha SS; Department of Chemistry & Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea. Electronic address: chajung@ewha.ac.kr.

Arch Biochem Biophys ; 693: 108570, 2020 10 30.

Article em En | MEDLINE | ID: mdl-32888908

Assuntos

Carbapenêmicos/farmacologia; Inibidores de beta-Lactamases/farmacologia; beta-Lactamases/efeitos dos fármacos; Catálise; Cristalografia por Raios X; Conformação Proteica; beta-Lactamases/química

Palavras-chave

Carbapenems; Catalytically-incompetent pose; Crystal structure of class C ß-lactamase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Carbapenêmicos / Inibidores de beta-Lactamases Idioma: En Revista: Arch Biochem Biophys Ano de publicação: 2020 Tipo de documento: Article

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