Developmental Trajectory of Height, Weight, and BMI in Children and Adolescents at Risk for Huntington's Disease: Effect of mHTT on Growth.
J Huntingtons Dis
; 9(3): 245-251, 2020.
Article
em En
| MEDLINE
| ID: mdl-32894247
ABSTRACT
BACKGROUND:
The gene (Huntingtin or HTT) causing Huntington's disease (HD) is vital for development and is expressed throughout the brain and body lifelong. The mutant form (mHTT) may influence growth and development.OBJECTIVE:
To determine the impact of mHTT on human measures of growth, including height, weight, and body mass index (BMI), between child and adolescent carriers of mHTT and control peers.METHODS:
Children ages 6-18 years of age (nâ=â186) at risk for HD were enrolled in the KidsHD study. For research purposes only, genetic testing was performed to classify participants as Gene-Expanded (GEâ=â78) or as Gene Non-Expanded (GNEâ=â108). Outcome measures included height, weight, and body mass index (BMI). Mixed models were used to determine if non-linear age trends differed between groups for BMI, height, and weight.RESULTS:
Differences were seen in the trajectory of BMI in which the GE group reached a plateau in late adolescence with no further increase, compared with a nearly linear increase in the GNE group. There was a significant sex interaction pattern where GE males were taller than GNE males in adolescence, in the presence of similar weight. In contrast, GE females weighed significantly less than their GNE counterparts in adolescence, in the presence of similar height.CONCLUSION:
Measures of growth are abnormal in child and adolescent carriers of mHTT, decades before HD onset. Although further studies are needed for replication, the current findings suggest that developmental aberrations may be systemic and a vital part of disease pathology.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Estatura
/
Peso Corporal
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Índice de Massa Corporal
/
Desenvolvimento Infantil
/
Desenvolvimento do Adolescente
/
Proteína Huntingtina
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Huntingtons Dis
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos