Low-Threshold Mechanosensitive VGLUT3-Lineage Sensory Neurons Mediate Spinal Inhibition of Itch by Touch.

Sakai, Kent; Sanders, Kristen M; Lin, Shing-Hong; Pavlenko, Darya; Funahashi, Hideki; Lozada, Taisa; Hao, Shuanglin; Chen, Chih-Cheng; Akiyama, Tasuku

Sakai, Kent; Sanders, Kristen M; Lin, Shing-Hong; Pavlenko, Darya; Funahashi, Hideki; Lozada, Taisa; Hao, Shuanglin; Chen, Chih-Cheng; Akiyama, Tasuku.

Afiliação

Sakai K; Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, Florida 33136.
Sanders KM; Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, Florida 33136.
Lin SH; Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan.
Pavlenko D; Department of Neurobiology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.
Funahashi H; Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, Florida 33136.
Lozada T; Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, Florida 33136.
Hao S; Department of Psychiatry, Faculty of Medicine, University of Miyazaki, Miyazaki City, Miyazaki 5200, Japan.
Chen CC; Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, Florida 33136.
Akiyama T; Department of Anesthesiology, University of Miami Miller School of Medicine, Miami, Florida, 33136.

J Neurosci ; 40(40): 7688-7701, 2020 09 30.

Article em En | MEDLINE | ID: mdl-32895292

Assuntos

Sistemas de Transporte de Aminoácidos Acídicos/metabolismo; Mecanorreceptores/metabolismo; Prurido/metabolismo; Limiar Sensorial; Tato; Potenciais de Ação; Sistemas de Transporte de Aminoácidos Acídicos/genética; Animais; Capsaicina/farmacologia; Di-Hidropiridinas/farmacologia; Feminino; Masculino; Mecanorreceptores/efeitos dos fármacos; Mecanorreceptores/fisiologia; Camundongos; Camundongos Endogâmicos C57BL; Naltrexona/análogos & derivados; Naltrexona/farmacologia; Inibição Neural; Compostos de Fenilureia/farmacologia; Fármacos do Sistema Sensorial/farmacologia

Palavras-chave

VGLUT3; itch; mice; optogenetics; spinal cord; touch

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Prurido / Limiar Sensorial / Tato / Sistemas de Transporte de Aminoácidos Acídicos / Mecanorreceptores Limite: Animals Idioma: En Revista: J Neurosci Ano de publicação: 2020 Tipo de documento: Article

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