Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons.
Mol Metab
; 42: 101070, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-32898712
ABSTRACT
The nucleus of the solitary tract (NTS) is emerging as a major site of action for the appetite-suppressive effects of leading pharmacotherapies currently investigated to treat obesity. However, our understanding of how NTS neurons regulate appetite remains incomplete. OBJECTIVES:
In this study, we used NTS nutrient sensing as an entry point to characterize stimulus-defined neuronal ensembles engaged by the NTS to produce physiological satiety.METHODS:
We combined histological analysis, neuroanatomical assessment using inducible viral tracing tools, and functional tests to characterize hindbrain-forebrain circuits engaged by NTS leucine sensing to suppress hunger.RESULTS:
We found that NTS detection of leucine engages NTS prolactin-releasing peptide (PrRP) neurons to inhibit AgRP neurons via a population of leptin receptor-expressing neurons in the dorsomedial hypothalamus. This circuit is necessary for the anorectic response to NTS leucine, the appetite-suppressive effect of high-protein diets, and the long-term control of energy balance.CONCLUSIONS:
These results extend the integrative capability of AgRP neurons to include brainstem nutrient sensing inputs.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regulação do Apetite
/
Núcleo Solitário
/
Comportamento Alimentar
Limite:
Animals
Idioma:
En
Revista:
Mol Metab
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Reino Unido