Clinical experience with azathioprine: the pros.
Neurology
; 38(7 Suppl 2): 20-3, 1988 Jul.
Article
em En
| MEDLINE
| ID: mdl-3290709
ABSTRACT
We performed a randomized, placebo-controlled, double-blind, comparative clinical trial of 36 weeks of methylprednisolone and 3 years of azathioprine in 98 patients in the chronic progression phase of multiple sclerosis (MS). We demonstrated a trend in favor of the combination therapy for limiting progression. The relapse rate in the azathioprine recipients was half that of the control group, and visual evoked potential latencies were stabilized in those who received the combination. We think that a therapeutic trial of continuous use of the combination of adrenal steroids with azathioprine would be worthwhile if administered early in the course of the disease.
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Base de dados:
MEDLINE
Assunto principal:
Azatioprina
/
Terapia de Imunossupressão
/
Esclerose Múltipla
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Neurology
Ano de publicação:
1988
Tipo de documento:
Article