Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.

Wang, Dandan; Yang, Xiaoxiao; Chen, Yuanli; Gong, Ke; Yu, Maoyun; Gao, Yongyao; Wu, Ximei; Hu, Huaqing; Liao, Chenzhong; Han, Jihong; Duan, Yajun

Wang, Dandan; Yang, Xiaoxiao; Chen, Yuanli; Gong, Ke; Yu, Maoyun; Gao, Yongyao; Wu, Ximei; Hu, Huaqing; Liao, Chenzhong; Han, Jihong; Duan, Yajun.

Afiliação

Wang D; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
Yang X; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
Chen Y; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
Gong K; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
Yu M; School of Biological and Pharmaceutical Engineering, West Anhui University, Lu'An, China.
Gao Y; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
Wu X; School of Medicine, Zhejiang University, Hangzhou, China.
Hu H; First Affiliated Hospital of Anhui Medical University, Hefei, China.
Liao C; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
Han J; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China; College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Mate
Duan Y; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China. Electronic address: yduan@hfut.edu.cn.

J Biol Chem ; 295(47): 15870-15882, 2020 11 20.

Article em En | MEDLINE | ID: mdl-32913121

Assuntos

Ácido Ascórbico/farmacologia; Regulação da Expressão Gênica/efeitos dos fármacos; Pró-Proteína Convertase 9/biossíntese; Receptores de LDL/biossíntese; Animais; Células Hep G2; Humanos; L-Gulonolactona Oxidase/genética; L-Gulonolactona Oxidase/metabolismo; Lipoproteínas LDL/genética; Lipoproteínas LDL/metabolismo; Camundongos; Camundongos Knockout; Pró-Proteína Convertase 9/genética; Receptores de LDL/genética

Palavras-chave

FoxO3a; LDL; LDLR; PCSK9; ascorbic acid; forkhead box P3 (FOXP3).; lipoprotein metabolism; lipoprotein receptor; low-density lipoprotein); proprotein convertase subtilisin/kexin type 9

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Ascórbico / Receptores de LDL / Regulação da Expressão Gênica / Pró-Proteína Convertase 9 Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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