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Feasibility of QSM in the human placenta.
Zun, Zungho; Kapse, Kushal; Quistorff, Jessica; Andescavage, Nickie; Gimovsky, Alexis C; Ahmadzia, Homa; Limperopoulos, Catherine.
Afiliação
  • Zun Z; Developing Brain Institute, Division of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, USA.
  • Kapse K; Division of Fetal and Transitional Medicine, Children's National Hospital, Washington, DC, USA.
  • Quistorff J; Department of Pediatrics, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.
  • Andescavage N; Department of Radiology, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.
  • Gimovsky AC; Developing Brain Institute, Division of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, USA.
  • Ahmadzia H; Developing Brain Institute, Division of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, USA.
  • Limperopoulos C; Department of Pediatrics, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.
Magn Reson Med ; 85(3): 1272-1281, 2021 03.
Article em En | MEDLINE | ID: mdl-32936489
PURPOSE: Quantitative susceptibility mapping (QSM) is an emerging tool for the precise characterization of human tissue, including regional oxygenation. A critical function of the human placenta is oxygen transfer to the developing fetus, which remains difficult to study in utero. The purpose of this study is to investigate the feasibility of performing QSM in the human placenta in utero. METHODS: In healthy pregnant women, 3D gradient echo data of the placenta were acquired with prospective respiratory gating at 1.5 Tesla and 3 Tesla. A brief period (6-7 min) of maternal hyperoxia was induced to increase placental oxygenation in a subset of women scanned at 3 Tesla, and data were acquired before and during oxygen administration. Susceptibility and T2∗ / R2∗ maps were reconstructed from gradient echo data, and mean and SD of these measures within the whole placenta were calculated. RESULTS: A total of 54 women were studied at a mean gestational age of 30.7 ± 4.2 (range: 24 5/7-38 4/7) weeks. Susceptibility and T2∗ maps demonstrated lobular contrast reflecting regional oxygenation difference at both field strengths. SD of susceptibilities, mean R2∗ , and SD of R2∗ of the placenta showed a linear relationship with gestational age (P < .01 for all). These measures were also responsive to maternal hyperoxia, and there was an increasing response with advancing gestational age (P < .01 for all). CONCLUSION: This study demonstrates the feasibility of performing placental QSM in pregnant women and supports the potential for placental QSM to provide noninvasive in vivo assessment of placental oxygenation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Hiperóxia Tipo de estudo: Observational_studies Limite: Female / Humans / Infant / Pregnancy Idioma: En Revista: Magn Reson Med Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Hiperóxia Tipo de estudo: Observational_studies Limite: Female / Humans / Infant / Pregnancy Idioma: En Revista: Magn Reson Med Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos