Wireless Programmable Recording and Stimulation of Deep Brain Activity in Freely Moving Humans.
Neuron
; 108(2): 322-334.e9, 2020 10 28.
Article
em En
| MEDLINE
| ID: mdl-32946744
ABSTRACT
Uncovering the neural mechanisms underlying human natural ambulatory behavior is a major challenge for neuroscience. Current commercially available implantable devices that allow for recording and stimulation of deep brain activity in humans can provide invaluable intrinsic brain signals but are not inherently designed for research and thus lack flexible control and integration with wearable sensors. We developed a mobile deep brain recording and stimulation (Mo-DBRS) platform that enables wireless and programmable intracranial electroencephalographic recording and electrical stimulation integrated and synchronized with virtual reality/augmented reality (VR/AR) and wearables capable of external measurements (e.g., motion capture, heart rate, skin conductance, respiration, eye tracking, and scalp EEG). When used in freely moving humans with implanted neural devices, this platform is adaptable to ecologically valid environments conducive to elucidating the neural mechanisms underlying naturalistic behaviors and to the development of viable therapies for neurologic and psychiatric disorders.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Desempenho Psicomotor
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Telemetria
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Encéfalo
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Estimulação Encefálica Profunda
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Eletroencefalografia
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Dispositivos Eletrônicos Vestíveis
Limite:
Humans
Idioma:
En
Revista:
Neuron
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2020
Tipo de documento:
Article