For Wnt Signaling, Fucosylation of LRP6 Is a Bitter Pill.
Cell Chem Biol
; 27(9): 1114-1116, 2020 09 17.
Article
em En
| MEDLINE
| ID: mdl-32946757
ABSTRACT
In this issue of Cell Chemical Biology, Hong et al. (2020) use in situ chemoenzymatic labeling to discover that fucosylation of the Wnt co-receptor LRP6 induces its endocytosis and downregulates Wnt/ß-catenin signaling. Their findings reveal a glycosylation-based mechanism for regulating Wnt signaling that could be targeted in cancer.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteína-6 Relacionada a Receptor de Lipoproteína de Baixa Densidade
/
Via de Sinalização Wnt
Idioma:
En
Revista:
Cell Chem Biol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos