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For Wnt Signaling, Fucosylation of LRP6 Is a Bitter Pill.
Shami Shah, Adnan; Sun, Hongyan; Baskin, Jeremy M.
Afiliação
  • Shami Shah A; Department of Chemistry and Chemical Biology and Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
  • Sun H; Department of Chemistry and Chemical Biology and Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
  • Baskin JM; Department of Chemistry and Chemical Biology and Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA. Electronic address: jeremy.baskin@cornell.edu.
Cell Chem Biol ; 27(9): 1114-1116, 2020 09 17.
Article em En | MEDLINE | ID: mdl-32946757
ABSTRACT
In this issue of Cell Chemical Biology, Hong et al. (2020) use in situ chemoenzymatic labeling to discover that fucosylation of the Wnt co-receptor LRP6 induces its endocytosis and downregulates Wnt/ß-catenin signaling. Their findings reveal a glycosylation-based mechanism for regulating Wnt signaling that could be targeted in cancer.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína-6 Relacionada a Receptor de Lipoproteína de Baixa Densidade / Via de Sinalização Wnt Idioma: En Revista: Cell Chem Biol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína-6 Relacionada a Receptor de Lipoproteína de Baixa Densidade / Via de Sinalização Wnt Idioma: En Revista: Cell Chem Biol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos