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Epidemiological evidence for a hereditary contribution to myasthenia gravis: a retrospective cohort study of patients from North America.
Green, Joshua D; Barohn, Richard J; Bartoccion, Emanuela; Benatar, Michael; Blackmore, Derrick; Chaudhry, Vinay; Chopra, Manisha; Corse, Andrea; Dimachkie, Mazen M; Evoli, Amelia; Florence, Julaine; Freimer, Miriam; Howard, James F; Jiwa, Theresa; Kaminski, Henry J; Kissel, John T; Koopman, Wilma J; Lipscomb, Bernadette; Maestri, Michelanglo; Marino, Mariapaola; Massey, Janice M; McVey, April; Mezei, Michelle M; Muppidi, Srikanth; Nicolle, Michael W; Oger, Joel; Pascuzzi, Robert M; Pasnoor, Mamatha; Pestronk, Alan; Provenzano, Carlo; Ricciardi, Roberta; Richman, David P; Rowin, Julie; Sanders, Donald B; Siddiqi, Zaeem; Soloway, Aimee; Wolfe, Gil I; Wulf, Charlie; Drachman, Daniel B; Traynor, Bryan J.
Afiliação
  • Green JD; Neuromuscular Diseases Research Unit, Laboratory of Neurogenetics, National Institute on Aging Intramural Research Program, Bethesda, Maryland, USA.
  • Barohn RJ; Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.
  • Bartoccion E; Institute of General Pathology, Catholic University, Fondazione Policlinico Universitario "A. Gemelli"-I.R.C.C.S, Rome, Italy.
  • Benatar M; Department of Neurology, University of Miami, Coral Gables, Florida, USA.
  • Blackmore D; Department of Medicine, University of Alberta Hospital, Edmonton, Alberta, Canada.
  • Chaudhry V; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Chopra M; Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Corse A; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Dimachkie MM; Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.
  • Evoli A; Istituto di Neurologia, Policlinico A. Gemelli IRCSS, Università Cattolica del S. Cuore, Rome, Italy.
  • Florence J; Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • Freimer M; Department of Neurology, Ohio State University Medical Center, Columbus, Ohio, USA.
  • Howard JF; Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Jiwa T; Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.
  • Kaminski HJ; Department of Neurology, George Washington University, Washington, DC, USA.
  • Kissel JT; Department of Neurology, Ohio State University Medical Center, Columbus, Ohio, USA.
  • Koopman WJ; Department of Clinical Neurosciences, London Health Sciences Centre, London, Ontario, Canada.
  • Lipscomb B; Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
  • Maestri M; Department of Neuroscience, University of Pisa, Pisa, Italy.
  • Marino M; Institute of General Pathology, Catholic University, Fondazione Policlinico Universitario "A. Gemelli"-I.R.C.C.S, Rome, Italy.
  • Massey JM; Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
  • McVey A; Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.
  • Mezei MM; Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.
  • Muppidi S; Department of Neurology and Neurosciences, Stanford University, Stanford, California, USA.
  • Nicolle MW; Division of Neurology, London Health Sciences Centre, London, Ontario, Canada.
  • Oger J; Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.
  • Pascuzzi RM; Department of Neurology, Indiana University-Purdue University, Indianapolis, Indiana, USA.
  • Pasnoor M; Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.
  • Pestronk A; Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • Provenzano C; Institute of General Pathology, Catholic University, Fondazione Policlinico Universitario "A. Gemelli"-I.R.C.C.S, Rome, Italy.
  • Ricciardi R; Department of Neuroscience, University of Pisa, Pisa, Italy.
  • Richman DP; Neurology, Center for Neuroscience, University of California, Davis, California, USA.
  • Rowin J; APAC Centers for Pain Management Wellness and Integrative Neurology, Westchester, Illinois, USA.
  • Sanders DB; Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
  • Siddiqi Z; Department of Medicine, University of Alberta Hospital, Edmonton, Alberta, Canada.
  • Soloway A; Department of Medicine, University of Alberta Hospital, Edmonton, Alberta, Canada.
  • Wolfe GI; Department of Neurology, University at Buffalo State University of New York, Buffalo, New York, United States.
  • Wulf C; Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • Drachman DB; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Traynor BJ; Neuromuscular Diseases Research Unit, Laboratory of Neurogenetics, National Institute on Aging Intramural Research Program, Bethesda, Maryland, USA traynorb@mail.nih.gov.
BMJ Open ; 10(9): e037909, 2020 09 18.
Article em En | MEDLINE | ID: mdl-32948566
ABSTRACT

OBJECTIVES:

To approximate the rate of familial myasthenia gravis and the coexistence of other autoimmune disorders in the patients and their families.

DESIGN:

Retrospective cohort study.

SETTING:

Clinics across North America.

PARTICIPANTS:

The study included 1032 patients diagnosed with acetylcholine receptor antibody (AChR)-positive myasthenia gravis.

METHODS:

Phenotype information of 1032 patients diagnosed with AChR-positive myasthenia gravis was obtained from clinics at 14 centres across North America between January 2010 and January 2011. A critical review of the epidemiological literature on the familial rate of myasthenia gravis was also performed.

RESULTS:

Among 1032 patients, 58 (5.6%) reported a family history of myasthenia gravis. A history of autoimmune diseases was present in 26.6% of patients and in 28.4% of their family members.

DISCUSSION:

The familial rate of myasthenia gravis was higher than would be expected for a sporadic disease. Furthermore, a high proportion of patients had a personal or family history of autoimmune disease. Taken together, these findings suggest a genetic contribution to the pathogenesis of myasthenia gravis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Miastenia Gravis Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: BMJ Open Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Miastenia Gravis Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: BMJ Open Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos