Glutamate Is a Noninvasive Metabolic Biomarker of IDH1-Mutant Glioma Response to Temozolomide Treatment.

Subramani, Elavarasan; Radoul, Marina; Najac, Chloe; Batsios, Georgios; Molloy, Abigail R; Hong, Donghyun; Gillespie, Anne Marie; Santos, Romelyn Delos; Viswanath, Pavithra; Costello, Joseph F; Pieper, Russell O; Ronen, Sabrina M

Subramani, Elavarasan; Radoul, Marina; Najac, Chloe; Batsios, Georgios; Molloy, Abigail R; Hong, Donghyun; Gillespie, Anne Marie; Santos, Romelyn Delos; Viswanath, Pavithra; Costello, Joseph F; Pieper, Russell O; Ronen, Sabrina M.

Afiliação

Subramani E; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Radoul M; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Najac C; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Batsios G; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Molloy AR; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Hong D; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Gillespie AM; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Santos RD; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Viswanath P; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Costello JF; Department of Neurological Surgery, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
Pieper RO; Department of Neurological Surgery, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
Ronen SM; Brain Tumor Research Center, University of California San Francisco, San Francisco, California.

Cancer Res ; 80(22): 5098-5108, 2020 11 15.

Article em En | MEDLINE | ID: mdl-32958546

Assuntos

Antineoplásicos Alquilantes/uso terapêutico; Biomarcadores Tumorais/metabolismo; Neoplasias Encefálicas/metabolismo; Glioma/metabolismo; Ácido Glutâmico/metabolismo; Isocitrato Desidrogenase/genética; Temozolomida/uso terapêutico; Animais; Neoplasias Encefálicas/tratamento farmacológico; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/patologia; Isótopos de Carbono; Feminino; Glioma/tratamento farmacológico; Glioma/genética; Glioma/patologia; Glucose/metabolismo; Glutamina/metabolismo; Humanos; Isocitrato Desidrogenase/metabolismo; Ácidos Cetoglutáricos/metabolismo; Espectroscopia de Ressonância Magnética/métodos; Camundongos; Camundongos Nus; Mutação; Engenharia de Proteínas; Ácido Pirúvico/metabolismo; Distribuição Aleatória; Resultado do Tratamento

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Biomarcadores Tumorais / Ácido Glutâmico / Antineoplásicos Alquilantes / Temozolomida / Glioma / Isocitrato Desidrogenase Tipo de estudo: Clinical_trials / Prognostic_studies / Screening_studies Limite: Animals / Female / Humans Idioma: En Revista: Cancer Res Ano de publicação: 2020 Tipo de documento: Article

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