Molecular basis for a new bovine model of Niemann-Pick type C disease.

Woolley, Shernae A; Tsimnadis, Emily R; Lenghaus, Cor; Healy, Peter J; Walker, Keith; Morton, Andrew; Khatkar, Mehar S; Elliott, Annette; Kaya, Ecem; Hoerner, Clarisse; Priestman, David A; Shepherd, Dawn; Platt, Frances M; Porebski, Ben T; Willet, Cali E; O'Rourke, Brendon A; Tammen, Imke

Woolley, Shernae A; Tsimnadis, Emily R; Lenghaus, Cor; Healy, Peter J; Walker, Keith; Morton, Andrew; Khatkar, Mehar S; Elliott, Annette; Kaya, Ecem; Hoerner, Clarisse; Priestman, David A; Shepherd, Dawn; Platt, Frances M; Porebski, Ben T; Willet, Cali E; O'Rourke, Brendon A; Tammen, Imke.

Afiliação

Woolley SA; Faculty of Science, Sydney School of Veterinary Science, The University of Sydney, Camden, NSW, Australia.
Tsimnadis ER; Faculty of Science, Sydney School of Veterinary Science, The University of Sydney, Camden, NSW, Australia.
Lenghaus C; Ararat, VIC, Australia.
Healy PJ; Harolds Cross, NSW, Australia.
Walker K; NSW Department of Primary Industries, Elizabeth Macarthur Agricultural Institute, Menangle, NSW, Australia.
Morton A; Wagga Wagga, NSW, Australia.
Khatkar MS; Faculty of Science, Sydney School of Veterinary Science, The University of Sydney, Camden, NSW, Australia.
Elliott A; NSW Department of Primary Industries, Elizabeth Macarthur Agricultural Institute, Menangle, NSW, Australia.
Kaya E; Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
Hoerner C; Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
Priestman DA; Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
Shepherd D; Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
Platt FM; Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
Porebski BT; Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Willet CE; The University of Sydney, Sydney Informatics Hub Core Research Facilities, Darlington, NSW, Australia.
O'Rourke BA; NSW Department of Primary Industries, Elizabeth Macarthur Agricultural Institute, Menangle, NSW, Australia.
Tammen I; Faculty of Science, Sydney School of Veterinary Science, The University of Sydney, Camden, NSW, Australia.

PLoS One ; 15(9): e0238697, 2020.

Article em En | MEDLINE | ID: mdl-32970694

Assuntos

Doença de Niemann-Pick Tipo C/genética; Doença de Niemann-Pick Tipo C/patologia; Sequência de Aminoácidos; Animais; Sequência de Bases; Bovinos; Células Cultivadas; Toxina da Cólera/metabolismo; Colesterol/metabolismo; DNA Complementar/genética; Modelos Animais de Doenças; Fibroblastos/patologia; Gangliosídeo G(M1)/metabolismo; Homozigoto; Mutação/genética; Proteína C1 de Niemann-Pick/química; Proteína C1 de Niemann-Pick/genética; Fenótipo; Polimorfismo de Nucleotídeo Único/genética; Polissacarídeos/metabolismo; RNA Mensageiro/genética; RNA Mensageiro/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Niemann-Pick Tipo C Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália

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