Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease.

Ahmed, Sahabuddin; Kwatra, Mohit; Ranjan Panda, Samir; Murty, U S N; Naidu, V G M

Ahmed, Sahabuddin; Kwatra, Mohit; Ranjan Panda, Samir; Murty, U S N; Naidu, V G M.

Afiliação

Ahmed S; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Assam 781101, India.
Kwatra M; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Assam 781101, India.
Ranjan Panda S; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Assam 781101, India.
Murty USN; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Assam 781101, India.
Naidu VGM; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Assam 781101, India. Electronic address: vgmnaidu@gmail.com.

Brain Behav Immun ; 91: 142-158, 2021 01.

Article em En | MEDLINE | ID: mdl-32971182

Assuntos

Microglia; Doença de Parkinson; Animais; Diterpenos; Inflamassomos; Camundongos; Camundongos Endogâmicos C57BL; Mitofagia; Proteína 3 que Contém Domínio de Pirina da Família NLR; Ubiquitina-Proteína Ligases

Palavras-chave

Andrographolide; Mitochondrial dysfunction; Mitophagy; NLRP3 inflammasome

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Microglia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Brain Behav Immun Assunto da revista: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia

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