Amelioration of cytotoxic-induced emesis with high-dose metoclopramide, dexamethasone and lorazepam.
Cancer Chemother Pharmacol
; 19(4): 331-4, 1987.
Article
em En
| MEDLINE
| ID: mdl-3297375
ABSTRACT
A double-blind randomised controlled trial comparing the antiemetic effects of sublingual lorazepam combined with high-dose, short course metoclopramide (3 mg/kg) infused twice 3 h apart with or without i.v. dexamethasone is reported. Sixty patients receiving a total of 209 cycles of potentially severely emetic cytotoxic chemotherapy were randomised to receive one or other antiemetic regimen. In those receiving platinum-based chemotherapy the addition of dexamethasone was associated with an improvement in freedom from nausea (P less than 0.01) and freedom from vomiting (P less than 0.05). In the non-platinum-based chemotherapy group the addition of dexamethasone led to a reduction in the duration and severity of nausea, and duration of vomiting (P less than 0.05 in each case). Both antiemetic regimens were well tolerated with a low incidence of adverse effects and could be administered easily in an outpatient setting.
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Base de dados:
MEDLINE
Assunto principal:
Vômito
/
Dexametasona
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Lorazepam
/
Metoclopramida
Tipo de estudo:
Clinical_trials
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Cancer Chemother Pharmacol
Ano de publicação:
1987
Tipo de documento:
Article