Targeting PIs to improve PTs:a new approach to treating genetic diseases of the proximal tubule.
Kidney Int
; 98(4): 824-826, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-32998810
Defective recycling of megalin consequent to impaired phosphatidylinositol metabolism has been implicated as a mechanism causing tubular proteinuria in patients with Lowe syndrome. In this issue, Berquez et al. describe an innovative approach using a clinically approved drug to "rebalance" phosphatidylinositols and restore megalin traffic in mouse and cell models of the disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteína-2 Relacionada a Receptor de Lipoproteína de Baixa Densidade
/
Túbulos Renais Proximais
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Kidney Int
Ano de publicação:
2020
Tipo de documento:
Article