The Inhibition of NLRP3 Inflammasome and IL-6 Production by <i>Hibiscus noldeae Baker f.</i> Derived Constituents Provides a Link to Its Anti-Inflammatory Therapeutic Potentials.

Tomani, Jean Claude Didelot; Kagisha, Vedaste; Tchinda, Alembert Tiabou; Jansen, Olivia; Ledoux, Allison; Vanhamme, Luc; Frederich, Michel; Muganga, Raymond; Souopgui, Jacob

The Inhibition of NLRP3 Inflammasome and IL-6 Production by Hibiscus noldeae Baker f. Derived Constituents Provides a Link to Its Anti-Inflammatory Therapeutic Potentials.

Tomani, Jean Claude Didelot; Kagisha, Vedaste; Tchinda, Alembert Tiabou; Jansen, Olivia; Ledoux, Allison; Vanhamme, Luc; Frederich, Michel; Muganga, Raymond; Souopgui, Jacob.

Afiliação

Tomani JCD; School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, P.O. Box 3286 Kigali, Rwanda.
Kagisha V; Department of Molecular Biology, Institute for Molecular Biology and Medicine, Université Libre de Bruxelles, 6041 Gosselies, Belgium.
Tchinda AT; School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, P.O. Box 3286 Kigali, Rwanda.
Jansen O; Laboratory of Pharmacognosy, Centre for Interdisciplinary Research on Medicines (CIRM), University of Liège, B36, 4000 Liège, Belgium.
Ledoux A; Laboratory of Phytochemistry, Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, Yaoundé P.O. Box 6163, Cameroon.
Vanhamme L; Laboratory of Pharmacognosy, Centre for Interdisciplinary Research on Medicines (CIRM), University of Liège, B36, 4000 Liège, Belgium.
Frederich M; Laboratory of Pharmacognosy, Centre for Interdisciplinary Research on Medicines (CIRM), University of Liège, B36, 4000 Liège, Belgium.
Muganga R; Department of Molecular Biology, Institute for Molecular Biology and Medicine, Université Libre de Bruxelles, 6041 Gosselies, Belgium.
Souopgui J; Laboratory of Pharmacognosy, Centre for Interdisciplinary Research on Medicines (CIRM), University of Liège, B36, 4000 Liège, Belgium.

Molecules ; 25(20)2020 Oct 14.

Article em En | MEDLINE | ID: mdl-33066442

Assuntos

Anti-Inflamatórios/farmacologia; Hibiscus/química; Inflamassomos/efeitos dos fármacos; Inflamação/tratamento farmacológico; Interleucina-6/antagonistas & inibidores; Proteína 3 que Contém Domínio de Pirina da Família NLR/antagonistas & inibidores; Extratos Vegetais/farmacologia; Animais; Inflamassomos/imunologia; Inflamassomos/metabolismo; Inflamação/imunologia; Inflamação/metabolismo; Inflamação/patologia; Interleucina-6/metabolismo; Macrófagos/efeitos dos fármacos; Macrófagos/imunologia; Macrófagos/metabolismo; Camundongos; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Células RAW 264.7

Palavras-chave

Hibiscus noldeae; IL-1ß; IL-6; Inflammasome; RAW264.7; THP-1; asthma; bio-guided fractionation; macrophage

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Interleucina-6 / Hibiscus / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR / Inflamação / Anti-Inflamatórios Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Ruanda

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