Dominant Nucleolus in the Progenitor Cell Using Human Bone Marrow Erythroid and Granulocytic Cell Lineages as a Model. A Morphological and Cytochemical Note.
Folia Biol (Praha)
; 66(3): 111-115, 2020.
Article
em En
| MEDLINE
| ID: mdl-33069190
ABSTRACT
Progenitor cells of the human erythroid and granulocytic cell lineages are characterized by the presence of several nucleoli. One of these nucleoli is larger and possesses more fibrillar centres than others. Such nucleolus is apparently dominant in respect of both size and main nucleolar function such as nucleolar-ribosomal RNA transcription. Such nucleolus is also visible in specimens using conventional visualization procedures, in contrast to smaller nucleoli. In the terminal differentiation nucleated stages of the erythroid and granulocytic development, dominant nucleoli apparently disappeared, since these cells mostly contained very small nucleoli of a similar size with one fibrillar centre. Thus, the easily visible dominant nucleoli appear to be useful markers of the progenitor cell state, such as proliferation, and differentiation potential.
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Base de dados:
MEDLINE
Assunto principal:
Células Precursoras Eritroides
/
Nucléolo Celular
/
Células Precursoras de Granulócitos
Limite:
Humans
Idioma:
En
Revista:
Folia Biol (Praha)
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
República Tcheca